Зарежда Събития
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Поредната сбирка на Колоквиума ще се състои на 10 септември 2018 г. (понеделник) от 16:15 часа в Заседателната зала на ИМИ-БАН, София, ул. „Акад. Г. Бончев”, блок 8.

Доклад на тема:

The New Field of Network Physiology: Mapping the Human Physiolome

ще изнесе проф. дфн Пламен Иванов от Теоретичния отдел, Институт по физика на твърдото тяло “Акад. Георги Наджаков”, БАН, Keck Laboratory for Network Physiology, Physics Department, Boston University Division of Sleep Medicine, Brigham and Women’s Hospital, Harvard Medical School.

Поканват се всички интересуващи се.

Ръководител на Колоквиума: акад. П. Попиванов

Резюме. The human organism is an integrated network where complex physiological systems, each with its own regulatory mechanisms, continuously interact to optimize and coordinate their function. Organ-to-organ interactions occur at multiple levels and spatiotemporal scales to produce distinct physiologic states: wake and sleep; light and deep sleep; consciousness and unconsciousness. Disrupting organ communications can lead to dysfunction of individual systems or to collapse of the entire organism (coma, multiple organ failure). Yet, we know almost nothing about the nature of the interactions between diverse organ systems and their collective role in maintaining health. Through the prism of concepts and approaches originating in statistical and computational physics and applied mathematics, we will present basic characteristics of individual organ systems, distinct forms of pairwise coupling between systems, and a new framework to identify and quantify networks of interactions among diverse organ systems. We will demonstrate how physiologic network topology and systems connectivity lead to integrated global behaviors representative of physiologic states and functions. We will discuss implications for further theoretical developments and practical applications within the context of the emerging field of Network Physiology. The presented investigations are initial steps in building a first atlas of dynamic interactions among organ systems and the Human Physiolome.


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